FDA, Center for Veterinary Medicine

[VendettaBoxers]

Note interaction warning just issued and reports of problems since drug was introduced in November 2007. This may not apply to anyone’s dogs I am mailing this too, but one can not be too careful concerning these types of drugs.

COMFORTIS® and ivermectin interaction Safety Warning NotificationToday the U.S. Food and Drug Administration (FDA) Center for Veterinary Medicine (CVM) is announcing that it has received reports of adverse reactions in dogs receiving the drug Comfortis® (spinosad) concurrently with high, extra-label doses of the drug ivermectin. The clinical signs of these adverse reactions are consistent with ivermectin toxicity.
Comfortis® (spinosad), manufactured by Elanco Animal Health, a division of Eli Lilly and Company, is a monthly oral, chewable tablet used for the prevention and treatment of flea infestations on dogs. Veterinarians who use high, extra-label doses of ivermectin to treat dogs with non-responsive demodectic mange and other conditions should be aware that some dogs have developed signs of ivermectin toxicity when ivermectin is used concurrently with Comfortis® (spinosad).
CVM and Elanco Animal Health are advising veterinarians that dogs receiving extra-label doses of ivermectin should not receive concurrent treatment with Comfortis® (spinosad).
CVM is working with Elanco Animal Health as they address this issue. Additional information regarding this safety warning can be obtained on the Elanco Animal Health website.
Lilly Companion Animal Health Technical Bulletin: Spinosad and the Extra-Label Use of High Dose Ivermectin for the Treatment of Generalized Demodicosis in Dogs - http://elms. xh1.lilly. com/10788_ 03_tech_Bulletin .pdf


Issued by:
FDA, Center for Veterinary Medicine,
Communications Staff, HFV-12
7519 Standish Place , Rockville , MD 20855
Telephone: (240) 276-9300 FAX: (240) 276-9115
Internet Web Site: http://www.fda. gov/cvm

[charlie2012]

Good to know. I just gave my dog a dose of ivermectin for whipworms the other day. Thanks for the information.

[FairyDogMother]

thanks for the info. will share it here too.

[rubyred]

Thank you so much for this info! This is really important information for all of us to know!